Carbamazepine and Thyroid Hormones

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Carbamazepine, serum thyroid hormones and myocardial function in epileptic patients.

Serum thyroid hormone and thyrotropin levels were assayed and the myocardial function was evaluated by measuring systolic time intervals both in 30 patients with epilepsy on long-term carbamazepine monotherapy and in 19 healthy volunteers. Serum thyroxine, free thyroxine and triiodothyronine levels were significantly lower (p < 0.001) in the patient group than in the control group and systolic ...

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  Background :Reproductive endocrine disorders and sexual dysfunction are common among men with epilepsy. We investigated sexual hormone serum levels among men with newly diagnosed epilepsy, before starting any antiepileptic drug (AED), and then after starting carbamazepine (CBZ), to determine the role and effects of epilepsy versus CBZ in creating reproductive endocrine disorders.   Methods : ...

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Thyroid hormones in children with epilepsy during long-term administration of carbamazepine and valproate.

OBJECTIVE This study evaluates the effects of long-term carbamazepine (CBZ) and valproate acid (VPA) therapy on thyroid function in epileptic children. DESIGN A prospective study performed in 32 newly diagnosed pediatric patients, subdivided into two groups: 18 patients treated with CBZ and 14 patients treated with VPA. Thirty-two sex- and age- matched subjects served as controls. METHODS S...

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Effects of carbamazepine on male reproductive hormones

BACKGROUND Reproductive endocrine disorders and sexual dysfunction are common among men with epilepsy. We investigated sexual hormone serum levels among men with newly diagnosed epilepsy, before starting any antiepileptic drug (AED), and then after starting carbamazepine (CBZ), to determine the role and effects of epilepsy versus CBZ in creating reproductive endocrine disorders. METHODS In th...

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An extensive review article on thyroid hormone published nearly 40 years ago (Barker, 1951) might have led one to suppose that little could be added to the subject of thyroid hormones and thermogenesis. However, a large number of new ideas have since emerged with respect to the mechanisms of action of thyroid hormones, although there is still considerable uncertainty as to how they function at ...

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ژورنال

عنوان ژورنال: Pediatric Neurology Briefs

سال: 2001

ISSN: 2166-6482,1043-3155

DOI: 10.15844/pedneurbriefs-15-9-6